UBE3D Gene Summary [Human]
Enables cyclin binding activity; ubiquitin protein ligase activity; and ubiquitin-like protein conjugating enzyme binding activity. Involved in protein autoubiquitination; protein monoubiquitination; and protein polyubiquitination. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | UBE3D |
| Official Name | ubiquitin protein ligase E3D [Source:HGNC Symbol;Acc:HGNC:21381] |
| Ensembl ID | ENSG00000118420 |
| Bio databases IDs | |
| Aliases | ubiquitin protein ligase E3D, UBCH10 binding protein with a hect-like domain |
| Synonyms | 2610018I03Rik, C6orf157, H10BH, LOC105377878, RGD1306773, UBE2CBP, ubiquitin protein ligase E3D, YJR141W |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UBE3D often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- HECT-like Ubiquitin-conjugating enzyme (E2)-binding
- ribonuclease inhibitor
- ubiquitin protein ligase activity
- enzyme binding
- enzyme
- protein binding
- cyclin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- esophageal squamous cell carcinoma
- Crohn disease
- esophageal squamous cell cancer
regulated by
- n-nitrosomethylbenzylamine
- methylphenidate
- phenethyl isothiocyanate
- black raspberry extract
role in cell
- expression in
- differentiation
- mitotic defect
- BI-2536 sensitivity
- camptothecin sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UBE3D gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- proteasomal ubiquitin-dependent protein catabolic process
- protein polyubiquitination
- protein monoubiquitination
- protein autoubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- cytosol
Molecular Function
What the gene product does at the molecular level
- small protein conjugating enzyme binding
- ubiquitin conjugating enzyme binding
- protein binding
- cyclin binding