SLPI Gene Summary [Human]
This gene encodes a secreted inhibitor which protects epithelial tissues from serine proteases. It is found in various secretions including seminal plasma, cervical mucus, and bronchial secretions, and has affinity for trypsin, leukocyte elastase, and cathepsin G. Its inhibitory effect contributes to the immune response by protecting epithelial surfaces from attack by endogenous proteolytic enzymes. This antimicrobial protein has antibacterial, antifungal and antiviral activity. [provided by RefSeq, Nov 2014]
Details
| Type | Protein Coding |
| Official Symbol | SLPI |
| Official Name | secretory leukocyte peptidase inhibitor [Source:HGNC Symbol;Acc:HGNC:11092] |
| Ensembl ID | ENSG00000124107 |
| Bio databases IDs | |
| Aliases | secretory leukocyte peptidase inhibitor, antileukoproteinase |
| Synonyms | ALK1, ALP, antileukoproteinase, BLPI, HUSI, HUSI-I, MPI, Secretory Leukocyte Inhibitory, secretory leukocyte peptidase inhibitor, Secretory Leukoprotease Inhibitor, SLP1, WAP4, WFDC4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLPI often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WAP
- endopeptidase inhibitor
- WAP-type (Whey Acidic Protein) 'four-disulfide core'
- mRNA binding
- serine protease inhibitor activity
- enzyme binding
- protein binding
- glycine serine rich domain
- DNA binding
Pathways
Biological processes and signaling networks where the SLPI gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastatic colorectal cancer
- bleeding
- airway hyperresponsiveness
- psoriasis
- endometriosis
- androgenic alopecia
- clear-cell ovarian carcinoma
- clear cell ovarian cancer
- endometrioid carcinoma
role in cell
- proliferation
- expression in
- production in
- activation in
- cell death
- growth
- phosphorylation in
- apoptosis
- cell viability
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- membrane fraction
- secretory granule lumen
- cell surface
- Extracellular Space
- cell periphery
- intracellular space
- cellular membrane
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- cytosol
- apical cytoplasm
- plasma
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLPI gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- innate immune response
- response to lipopolysaccharide
- antibacterial humoral response
- negative regulation of protein binding
- negative regulation of viral genome replication
- modification of morphology or physiology of other organism
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- specific granule lumen
- Golgi apparatus
- extracellular region
Molecular Function
What the gene product does at the molecular level
- DNA binding
- serine-type endopeptidase inhibitor activity
- endopeptidase inhibitor activity
- protein binding
- mRNA binding
- enzyme binding