FBXL5 Gene Summary [Human]
This gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbls class and, in addition to an F-box, contains several tandem leucine-rich repeats. Alternatively spliced transcript variants have been described for this locus. [provided by RefSeq, Aug 2010]
Details
| Type | Protein Coding |
| Official Symbol | FBXL5 |
| Official Name | F-box and leucine rich repeat protein 5 [Source:HGNC Symbol;Acc:HGNC:13602] |
| Ensembl ID | ENSG00000118564 |
| Bio databases IDs | |
| Aliases | F-box and leucine rich repeat protein 5 |
| Synonyms | FBL4, FBL5, F-box and leucine-rich repeat protein 5, Fir4, FLR1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FBXL5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- F-box domain
- Hemerythrin family
- F-box domain superfamily
- Leucine-rich repeat - CC (cysteine-containing) subfamily
- F-box-like
- iron ion binding
- enzyme
- protein binding
- Leucine Rich repeats (2 copies)
Pathways
Biological processes and signaling networks where the FBXL5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- liver cancer
- liver damage
- growth failure
- bleeding
- microcytosis
role in cell
- apoptosis
- expression in
- proliferation
- homeostasis in
- accumulation in
- palbociclib resistance
- pravastatin resistance
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FBXL5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cellular iron ion homeostasis
- multicellular organismal iron ion homeostasis
- SCF-dependent proteasomal ubiquitin-dependent protein catabolic process
- positive regulation of protein catabolic process
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- perinuclear region of cytoplasm
- ubiquitin ligase complex
- cytosol
- SCF ubiquitin ligase complex
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein binding
- iron ion binding
- 2 iron, 2 sulfur cluster binding