IGFBP1 Gene Summary [Human]
This gene is a member of the insulin-like growth factor binding protein (IGFBP) family and encodes a protein with an IGFBP N-terminal domain and a thyroglobulin type-I domain. The encoded protein, mainly expressed in the liver, circulates in the plasma and binds both insulin-like growth factors (IGFs) I and II, prolonging their half-lives and altering their interaction with cell surface receptors. This protein is important in cell migration and metabolism. Low levels of this protein may be associated with impaired glucose tolerance, vascular disease and hypertension in human patients. [provided by RefSeq, Aug 2017]
Details
| Type | Protein Coding |
| Official Symbol | IGFBP1 |
| Official Name | insulin like growth factor binding protein 1 [Source:HGNC Symbol;Acc:HGNC:5469] |
| Ensembl ID | ENSG00000146678 |
| Bio databases IDs | |
| Aliases | insulin like growth factor binding protein 1, placental protein 12, amniotic fluid binding protein, alpha-pregnancy-associated endometrial globulin, growth hormone independent-binding protein, binding protein-28, binding protein-26, binding protein-25, IGF-binding protein 1 |
| Synonyms | AFBP, hIGFBP-1, IBP1, IGFBA, IGF-BP25, IGFBP-RP1, insulin-like growth factor binding protein 1, PP12 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human IGFBP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- TY
- RGD motif
- insulin-like growth factor binding
- protein binding
- receptor binding
- Insulin-like growth factor binding protein
Pathways
Biological processes and signaling networks where the IGFBP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioblastoma
- lung squamous cell carcinoma
- squamous cell lung cancer
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- metabolic disorder
- hepatic steatosis
- cholangiocarcinoma
- cholangiocarcinoma cancer
role in cell
- expression in
- proliferation
- apoptosis
- phosphorylation in
- activation in
- migration
- quantity
- growth
- adhesion
- area
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Golgi Apparatus
- endoplasmic reticulum lumen
- neuromuscular junctions
- plasma
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human IGFBP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of canonical Wnt receptor signaling pathway
- positive regulation of cell growth
- insulin receptor signaling pathway
- signal transduction
- response to organic cyclic compound
- regulation of insulin-like growth factor receptor signaling pathway
- tissue regeneration
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum lumen
- extracellular space
- Golgi apparatus
- extracellular region
Molecular Function
What the gene product does at the molecular level
- protein binding
- receptor binding
- insulin-like growth factor binding
- insulin-like growth factor I binding
- insulin-like growth factor II binding