TRIM32 Gene Summary [Human]
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein localizes to cytoplasmic bodies. The protein has also been localized to the nucleus, where it interacts with the activation domain of the HIV-1 Tat protein. The Tat protein activates transcription of HIV-1 genes. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | TRIM32 |
| Official Name | tripartite motif containing 32 [Source:HGNC Symbol;Acc:HGNC:16380] |
| Ensembl ID | ENSG00000119401 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 32 |
| Synonyms | 1810045E12Rik, 3f3, BBS11, HT2A, LGMD2H, LGMDR8, TATIP, tripartite motif-containing 32, ZFP117 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM32 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- ubiquitin protein ligase activity
- protein binding activity, bridging
- transcription factor binding
- coiled-coil domain
- ubiquitin binding
- Ring finger domain
- protein binding
- NHL repeat unit of beta-propeller proteins
- identical protein binding
- RNA binding
- myosin binding
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- RING/Ubox like zinc-binding domain
- NHL repeat
- Tat binding domain
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- Box B domain
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- Bardet-Biedl syndrome
- Bardet-Biedl syndrome type 11
- limb-girdle muscular dystrophy type 2H
- retinal dystrophy
- head and neck squamous cell carcinoma
- head and neck squamous cell cancer
- organismal death
- HER2 negative hormone receptor negative breast cancer
- squamous-cell carcinoma
role in cell
- expression in
- apoptosis
- phosphorylation in
- assembly
- degradation in
- migration
- growth
- autophagy by
- activity
- cell cycle progression
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- perinuclear region
- centrosome
- Mitochondria
- sarcomere
- granules
- cytoplasmic aggregates
- cytosol
- autophagic vacuoles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM32 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- muscle cell homeostasis
- actin ubiquitination
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- response to starvation
- positive regulation of neuron differentiation
- positive regulation of cell cycle
- response to UV
- positive regulation of proteolysis
- fat cell differentiation
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of NF-kappaB transcription factor activity
- autophagic vacuole assembly
- response to oxidative stress
- positive regulation of cell growth
- positive regulation of transcription, DNA-dependent
- negative regulation of fibroblast proliferation
- free ubiquitin chain polymerization
- protein K48-linked ubiquitination
- negative regulation of toll-like receptor 4 signaling pathway
- protein polyubiquitination
- positive regulation of protein catabolic process
- ubiquitin-dependent protein catabolic process
- tissue homeostasis
- positive regulation of autophagy
- positive regulation of striated muscle cell differentiation
- innate immune response
- positive regulation of autophagic vacuole assembly
- protein K63-linked ubiquitination
- positive regulation of neurogenesis
- response to tumor necrosis factor
- negative regulation of viral transcription
- positive regulation of cell migration
- positive regulation of cell motility
- protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- centrosome
- cytoplasm
- mitochondrion
- cytosol
- endoplasmic reticulum
- autophagic vacuole
- striated muscle myosin thick filament
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- zinc ion binding
- identical protein binding
- RNA binding
- protein binding
- transcription coactivator activity
- ubiquitin binding
- Tat protein binding
- myosin binding
- translation initiation factor binding
- protein binding, bridging