SFRP5 Gene Summary [Human]
Secreted frizzled-related protein 5 (SFRP5) is a member of the SFRP family that contains a cysteine-rich domain homologous to the putative Wnt-binding site of Frizzled proteins. SFRPs act as soluble modulators of Wnt signaling. SFRP5 and SFRP1 may be involved in determining the polarity of photoreceptor cells in the retina. SFRP5 is highly expressed in the retinal pigment epithelium, and moderately expressed in the pancreas. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | SFRP5 |
| Official Name | secreted frizzled related protein 5 [Source:HGNC Symbol;Acc:HGNC:10779] |
| Ensembl ID | ENSG00000120057 |
| Bio databases IDs | |
| Aliases | secreted frizzled related protein 5, secreted apoptosis related protein 3 |
| Synonyms | AI605071, SARP3, secreted frizzled-related protein 5, secreted frizzled-related sequence protein 5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SFRP5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NTR_like
- Fz domain
- transmembrane receptor
- cysteine rich domain
- CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
Pathways
Biological processes and signaling networks where the SFRP5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- mesothelioma formation
- growth failure
- atrial fibrillation
- malignant mesothelioma
- hydronephrosis
role in cell
- apoptosis
- phosphorylation in
- accumulation
- expression in
- proliferation
- quantity
- differentiation
- growth
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SFRP5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of cell proliferation
- establishment or maintenance of cell polarity
- negative regulation of non-canonical Wnt receptor signaling pathway
- anatomical structure morphogenesis
- digestive tract morphogenesis
- visual perception
- regulation of transcription from RNA polymerase II promoter
- negative regulation of canonical Wnt receptor signaling pathway
- apoptotic process
- cell differentiation
- canonical Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
- non-canonical Wnt receptor signaling pathway
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- Wnt-protein binding