Sfrp5 Gene Summary [Mouse]
Predicted to enable Wnt-protein binding activity. Acts upstream of or within several processes, including convergent extension involved in axis elongation; negative regulation of JUN kinase activity; and post-anal tail morphogenesis. Predicted to be located in extracellular region. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; ear; early conceptus; nervous system; and reproductive system. Orthologous to human SFRP5 (secreted frizzled related protein 5). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Sfrp5 |
| Official Name | secreted frizzled-related sequence protein 5 [Source:MGI Symbol;Acc:MGI:1860298] |
| Ensembl ID | ENSMUSG00000018822 |
| Bio databases IDs | |
| Aliases | secreted frizzled-related sequence protein 5 |
| Synonyms | AI605071, SARP3, secreted frizzled-related protein 5, secreted frizzled-related sequence protein 5 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Sfrp5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- NTR_like
- Fz domain
- transmembrane receptor
- cysteine rich domain
- CRD_domain cysteine-rich domain, also known as Fz (frizzled) domain
Pathways
Biological processes and signaling networks where the Sfrp5 gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- liver cancer
- epithelial cancer
- mesothelioma formation
- growth failure
- atrial fibrillation
- malignant mesothelioma
- hydronephrosis
role in cell
- apoptosis
- phosphorylation in
- accumulation
- expression in
- proliferation
- quantity
- differentiation
- growth
- chemotaxis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Extracellular Space
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Sfrp5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- negative regulation of cell proliferation
- establishment or maintenance of cell polarity
- negative regulation of non-canonical Wnt receptor signaling pathway
- anatomical structure morphogenesis
- digestive tract morphogenesis
- visual perception
- regulation of transcription from RNA polymerase II promoter
- negative regulation of canonical Wnt receptor signaling pathway
- apoptotic process
- cell differentiation
- canonical Wnt receptor signaling pathway
- negative regulation of Wnt receptor signaling pathway
- non-canonical Wnt receptor signaling pathway
- negative regulation of protein kinase B signaling cascade
Cellular Component
Where in the cell the gene product is active
- extracellular space
Molecular Function
What the gene product does at the molecular level
- Wnt-protein binding