INSL6 Gene Summary [Human]
The protein encoded by this gene contains a classical signature of the insulin superfamily and is significantly similar to relaxin and relaxin-like factor. This gene is preferentially expressed in testis. Its expression in testis is restricted to interstitial cells surrounding seminiferous tubules, which suggests a role in sperm development and fertilization. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | INSL6 |
| Official Name | insulin like 6 [Source:HGNC Symbol;Acc:HGNC:6089] |
| Ensembl ID | ENSG00000120210 |
| Bio databases IDs | |
| Aliases | insulin like 6, relaxin/insulin-like factor 1 |
| Synonyms | insulin-like 6, INSULIN-LIKE FACTOR 6, RIF1 |
| Species | Human, Homo sapiens |
| Orthologies |
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- psoriatic arthritis
- azoospermia
- oligozoospermia
- asthenozoospermia
regulates
- ERK1/2
role in cell
- proliferation
- apoptosis
- motility
- abnormal morphology
- development
- fertilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- perinuclear region
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human INSL6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- hormone activity