Insl6 Gene Summary [Mouse]
Predicted to enable hormone activity. Acts upstream of or within several processes, including flagellated sperm motility; male gonad development; and spermatid development. Predicted to be located in extracellular region. Is expressed in several structures, including colon; gonad; heart; hemolymphoid system gland; and liver. Orthologous to human INSL6 (insulin like 6). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Insl6 |
| Official Name | insulin-like 6 [Source:MGI Symbol;Acc:MGI:1351595] |
| Ensembl ID | ENSMUSG00000050957 |
| Bio databases IDs | |
| Aliases | insulin-like 6 |
| Synonyms | insulin-like 6, INSULIN-LIKE FACTOR 6, RIF1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Parkinson disease
- psoriatic arthritis
- azoospermia
- oligozoospermia
- asthenozoospermia
regulates
- ERK1/2
role in cell
- proliferation
- apoptosis
- motility
- abnormal morphology
- development
- fertilization
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- perinuclear region
- Golgi Apparatus
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Insl6 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
Cellular Component
Where in the cell the gene product is active
- extracellular region
Molecular Function
What the gene product does at the molecular level
- hormone activity