LRRFIP2 Gene Summary [Human]
The protein encoded by this gene, along with MYD88, binds to the cytosolic tail of toll-like receptor 4 (TLR4), which results in activation of nuclear factor kappa B signaling. The ubiquitin-like protein FAT10 prevents the interaction of the encoded protein and TLR4, thereby inactivating the nuclear factor kappa B signaling pathway. In addition, this protein can downregulate the NLRP3 inflammasome by recruiting the caspase-1 inhibitor Flightless-I to the inflammasome complex. [provided by RefSeq, Jan 2017]
Details
| Type | Protein Coding |
| Official Symbol | LRRFIP2 |
| Official Name | LRR binding FLII interacting protein 2 [Source:HGNC Symbol;Acc:HGNC:6703] |
| Ensembl ID | ENSG00000093167 |
| Bio databases IDs | |
| Aliases | LRR binding FLII interacting protein 2 |
| Synonyms | 5133400F20Rik, HUFI-2, leucine rich repeat (in FLII) interacting protein 2, LRR binding FLII interacting protein 2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LRRFIP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Autophagy protein 16 (ATG16)
- LRRFIP family
- LRR-domain binding
- Domain of unknown function (DUF4795)
- protein binding
- Calcium binding and coiled-coil domain (CALCOCO1) like
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostate cancer
- colon cancer
- bipolar disorder
- COVID-19
- metastasis
- flu
- idiopathic scoliosis
- colon adenoma
- colon adenoma formation
- metabolic syndrome X
role in cell
- expression in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LRRFIP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of transcription, DNA-dependent
- Wnt receptor signaling pathway
Molecular Function
What the gene product does at the molecular level
- protein binding
- LRR domain binding