LYPLA1 Gene Summary [Human]
This gene encodes a member of the alpha/beta hydrolase superfamily. The encoded protein functions as a homodimer, exhibiting both depalmitoylating as well as lysophospholipase activity, and may be involved in Ras localization and signaling. Alternate splicing results in multiple transcript variants. Pseudogenes of this gene have been defined on chromosomes 4, 6, and 7. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | LYPLA1 |
| Official Name | lysophospholipase 1 [Source:HGNC Symbol;Acc:HGNC:6737] |
| Ensembl ID | ENSG00000120992 |
| Bio databases IDs | |
| Aliases | lysophospholipase 1, acyl-protein thioesterase 1 |
| Synonyms | 25KDL, Acyl-Protein Thioesterase, APT-1, Gm39587, hAPT1, LOC105375839, LPL1, LPL-I, lysophospholipase 1, lysoPLA, Pla1a, RP11 30L156 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LYPLA1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Serine hydrolase (FSH1)
- lysophospholipase
- alpha/beta hydrolases
- Phospholipase/Carboxylesterase
- lipase
- enzyme
- palmitoyl-(protein) hydrolase
- protein binding
- phospholipase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- IgA nephropathy
- diabetic nephropathy
- membranous glomerulonephritis
- fibrosis
- lung adenocarcinoma
- lung adenocarcinoma formation
- breast cancer
- chronic lymphocytic leukemia
role in cell
- apoptosis
- invasion by
- depalmitoylation in
- palmitoylation in
- volume
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- Endoplasmic Reticulum
- Mitochondria
- cytosol
- nucleoplasm
- nuclear envelope
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LYPLA1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fatty acid transport
- protein depalmitoylation
- fatty acid metabolic process
- negative regulation of Golgi to plasma membrane protein transport
Cellular Component
Where in the cell the gene product is active
- nuclear membrane
- extracellular vesicular exosome
- cytoplasm
- cytosol
- endoplasmic reticulum
- plasma membrane
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- lysophospholipase activity
- protein binding
- palmitoyl-(protein) hydrolase activity
- lipase activity
- carboxylic ester hydrolase activity
- phospholipase activity