Mnd1 Gene Summary [Mouse]
Predicted to enable double-stranded DNA binding activity. Predicted to be involved in homologous chromosome pairing at meiosis and reciprocal meiotic recombination. Predicted to be located in nucleus. Is expressed in branchial arch; central nervous system; embryo; forelimb bud; and somite. Orthologous to human MND1 (meiotic nuclear divisions 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Mnd1 |
| Official Name | meiotic nuclear divisions 1 [Source:MGI Symbol;Acc:MGI:1924165] |
| Ensembl ID | ENSMUSG00000033752 |
| Bio databases IDs | |
| Aliases | meiotic nuclear divisions 1 |
| Synonyms | 2610034E18Rik, GAJ, meiotic nuclear divisions 1, RGD1309007, TAC3 variant 2 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Mnd1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Mnd1 HTH domain
- coiled-coil domain
- protein binding
- Leucine zipper with capping helix domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- organismal death
- COVID-19
- gastric adenocarcinoma
- gastric epithelial cancer
- infection by HIV-1
role in cell
- proliferation
- talazoparib sensitivity
- G1 phase
- synapsis in
- homologous recombination repair in
- oxaliplatin sensitivity
- olaparib sensitivity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Mnd1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- reciprocal meiotic recombination
- synapsis
Cellular Component
Where in the cell the gene product is active
- nucleus
Molecular Function
What the gene product does at the molecular level
- protein binding
- double-stranded DNA binding