GPR183 Gene Summary [Human]
This gene was identified by the up-regulation of its expression upon Epstein-Barr virus infection of primary B lymphocytes. This gene is predicted to encode a G protein-coupled receptor that is most closely related to the thrombin receptor. Expression of this gene was detected in B-lymphocyte cell lines and lymphoid tissues but not in T-lymphocyte cell lines or peripheral blood T lymphocytes. The function of this gene is unknown. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | GPR183 |
| Official Name | G protein-coupled receptor 183 [Source:HGNC Symbol;Acc:HGNC:3128] |
| Ensembl ID | ENSG00000169508 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 183, EBV-induced G-protein coupled receptor 2 |
| Synonyms | EBI2, G protein-coupled receptor 183, hEBI2, LOC686966 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPR183 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- oxysterol binding
- Cholecystokinin A receptor, N-terminal
- CW/FxP motif
- transmembrane domain
- 7 transmembrane receptor (rhodopsin family)
- basic domain
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the GPR183 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- Alzheimer disease
- prostate cancer
- septic shock
- androgenic alopecia
- early missed abortion
- systemic lupus erythematosus
- sepsis
- aortic valve calcification
- adult T-cell leukemia/lymphoma
role in cell
- activation in
- expression in
- phosphorylation in
- migration
- proliferation
- differentiation
- chemotaxis
- motility
- guidance
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GPR183 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- dendritic cell homeostasis
- G-protein coupled receptor signaling pathway
- adaptive immune response
- B cell activation involved in immune response
- osteoclast differentiation
- mature B cell differentiation involved in immune response
- immune response
- T cell chemotaxis
- humoral immune response
- dendritic cell chemotaxis
- positive regulation of ERK1 and ERK2 cascade
- positive regulation of B cell proliferation
- leukocyte chemotaxis
- regulation of astrocyte chemotaxis
Cellular Component
Where in the cell the gene product is active
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- oxysterol binding