LAX1 Gene Summary [Human]
Enables SH2 domain binding activity and protein kinase binding activity. Involved in several processes, including B cell activation; negative regulation of MAP kinase activity; and negative regulation of T cell activation. Located in Golgi apparatus; cytosol; and plasma membrane. Is integral component of membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | LAX1 |
| Official Name | lymphocyte transmembrane adaptor 1 [Source:HGNC Symbol;Acc:HGNC:26005] |
| Ensembl ID | ENSG00000122188 |
| Bio databases IDs | |
| Aliases | lymphocyte transmembrane adaptor 1, LAT-like membrane associated protein, linker for activation of x cells |
| Synonyms | A530029E09, E430019B13Rik, LAX, lymphocyte transmembrane adaptor 1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LAX1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Lymphocyte activation family X
- protein kinase binding
- SH2-domain binding
- transmembrane domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- immune thrombocytopenia
- breast carcinoma
- diabetic nephropathy
- Crohn disease
role in cell
- survival
- response
- activation
- function
- development
- degranulation
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- cytosol
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LAX1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- antigen receptor-mediated signaling pathway
- immune response
- negative regulation of MAPK cascade
- adaptive immune response
- negative regulation of T cell activation
- B cell activation
- lymphocyte activation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- membrane raft
- membrane
- cytosol
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- SH2 domain binding