Lax1 Gene Summary [Mouse]
Predicted to enable SH2 domain binding activity and protein kinase binding activity. Acts upstream of or within antigen receptor-mediated signaling pathway and lymphocyte activation. Predicted to be located in Golgi apparatus; cytosol; and membrane. Predicted to be active in plasma membrane. Orthologous to human LAX1 (lymphocyte transmembrane adaptor 1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Lax1 |
| Official Name | lymphocyte transmembrane adaptor 1 [Source:MGI Symbol;Acc:MGI:2443362] |
| Ensembl ID | ENSMUSG00000051998 |
| Bio databases IDs | |
| Aliases | lymphocyte transmembrane adaptor 1 |
| Synonyms | A530029E09, E430019B13Rik, LAX, lymphocyte transmembrane adaptor 1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Lax1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- Lymphocyte activation family X
- protein kinase binding
- SH2-domain binding
- transmembrane domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- immune thrombocytopenia
- breast carcinoma
- diabetic nephropathy
- Crohn disease
role in cell
- survival
- response
- activation
- function
- development
- degranulation
- signal transduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Plasma Membrane
- Golgi Apparatus
- cytosol
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Lax1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- antigen receptor-mediated signaling pathway
- immune response
- negative regulation of MAPK cascade
- adaptive immune response
- negative regulation of T cell activation
- B cell activation
- lymphocyte activation
- intracellular signal transduction
Cellular Component
Where in the cell the gene product is active
- membrane raft
- membrane
- cytosol
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- SH2 domain binding