UBASH3A Gene Summary [Human]
This gene encodes one of two family members belonging to the T-cell ubiquitin ligand (TULA) family. Both family members can negatively regulate T-cell signaling. This family member can facilitate growth factor withdrawal-induced apoptosis in T cells, which may occur via its interaction with AIF, an apoptosis-inducing factor. Alternative splicing of this gene results in multiple transcript variants. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | UBASH3A |
| Official Name | ubiquitin associated and SH3 domain containing A [Source:HGNC Symbol;Acc:HGNC:12462] |
| Ensembl ID | ENSG00000160185 |
| Bio databases IDs | |
| Aliases | ubiquitin associated and SH3 domain containing A, T-cell ubiquitin ligand protein |
| Synonyms | 5830413C03Rik, C330001M22, CLIP4, Gm4102, LOC100044380, LOC100134052, STS-2, TULA, TULA-1, ubiquitin associated and SH3 domain containing A, ubiquitin associated and SH3 domain containing, A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human UBASH3A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- Histidine phosphatase superfamily (branch 1)
- Phosphoglycerate mutase family
- proline glycine methionine motif
- enzyme
- protein binding
- alpha-ribazole phosphatase
- Histidine phosphatase domain
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- non-insulin-dependent diabetes mellitus
- rheumatoid arthritis
- insulin-dependent diabetes mellitus
- autoimmune disease
- diabetic nephropathy
- Graves disease
- vitiligo
- hypothyroidism
- experimental autoimmune encephalomyelitis
- celiac disease
role in cell
- apoptosis
- number
- binding in
- proliferation
- transformation
- tyrosine phosphorylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- cytosol
- nucleoplasm
- nuclear speckles
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human UBASH3A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of T cell receptor signaling pathway
- regulation of cytokine production
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytoplasm
- nuclear speck
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding