Slpi Gene Summary [Mouse]
Enables endopeptidase inhibitor activity. Involved in antibacterial humoral response; innate immune response; and response to lipopolysaccharide. Located in extracellular space. Is expressed in embryo; liver left lobe; liver right lobe; and ureter. Orthologous to human SLPI (secretory leukocyte peptidase inhibitor). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Slpi |
| Official Name | secretory leukocyte peptidase inhibitor [Source:MGI Symbol;Acc:MGI:109297] |
| Ensembl ID | ENSMUSG00000017002 |
| Bio databases IDs | |
| Aliases | secretory leukocyte peptidase inhibitor |
| Synonyms | ALK1, ALP, antileukoproteinase, BLPI, HUSI, HUSI-I, MPI, Secretory Leukocyte Inhibitory, secretory leukocyte peptidase inhibitor, Secretory Leukoprotease Inhibitor, SLP1, WAP4, WFDC4 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Slpi often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- WAP
- endopeptidase inhibitor
- WAP-type (Whey Acidic Protein) 'four-disulfide core'
- mRNA binding
- serine protease inhibitor activity
- enzyme binding
- protein binding
- glycine serine rich domain
- DNA binding
Pathways
Biological processes and signaling networks where the Slpi gene in mouse plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastatic colorectal cancer
- bleeding
- airway hyperresponsiveness
- psoriasis
- endometriosis
- androgenic alopecia
- clear-cell ovarian carcinoma
- clear cell ovarian cancer
- endometrioid carcinoma
role in cell
- proliferation
- expression in
- production in
- activation in
- cell death
- growth
- phosphorylation in
- apoptosis
- cell viability
- activation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- nuclear fraction
- membrane fraction
- secretory granule lumen
- cell surface
- Extracellular Space
- cell periphery
- intracellular space
- cellular membrane
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- cytosol
- apical cytoplasm
- plasma
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Slpi gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- immune response
- innate immune response
- response to lipopolysaccharide
- antibacterial humoral response
- negative regulation of protein binding
- negative regulation of viral genome replication
- modification of morphology or physiology of other organism
Cellular Component
Where in the cell the gene product is active
- extracellular space
- extracellular vesicular exosome
- specific granule lumen
- Golgi apparatus
- extracellular region
Molecular Function
What the gene product does at the molecular level
- DNA binding
- serine-type endopeptidase inhibitor activity
- endopeptidase inhibitor activity
- protein binding
- mRNA binding
- enzyme binding