Btn1a1 Gene Summary [Mouse]
Predicted to enable signaling receptor binding activity. Predicted to be involved in T cell receptor signaling pathway and regulation of cytokine production. Predicted to be located in membrane. Predicted to be active in external side of plasma membrane. Is expressed in central nervous system; genitourinary system; and heart valve. Orthologous to human BTN1A1 (butyrophilin subfamily 1 member A1). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Btn1a1 |
| Official Name | butyrophilin, subfamily 1, member A1 [Source:MGI Symbol;Acc:MGI:103118] |
| Ensembl ID | ENSMUSG00000000706 |
| Bio databases IDs | |
| Aliases | butyrophilin, subfamily 1, member A1 |
| Synonyms | BT, BTN, BTN1, butyrophilin subfamily 1 member A1, Butyrophilin, subfamily 1, member a1 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Btn1a1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- extracellular domain
- signaling receptor activity
- SPRY domain
- Immunoglobulin V-Type
- immunoglobulin domain
- Immunoglobulin like
- Immunoglobulin I-set domain
- protein binding
- Ig-like V domain
- associated with SPRY domains
- Immunoglobulin V-set domain
- SPRY-associated domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- experimental autoimmune encephalomyelitis
- diabetic nephropathy
role in cell
- proliferation
- metabolism by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- cellular membrane
- apical cell surfaces
- exosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Btn1a1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cytokine production
- T cell receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular space
- external side of plasma membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- signaling receptor activity
- receptor binding