GPR18 Gene Summary [Human]
Predicted to enable G protein-coupled receptor activity. Predicted to be involved in positive regulation of Rho protein signal transduction and positive regulation of cytosolic calcium ion concentration involved in phospholipase C-activating G protein-coupled signaling pathway. Predicted to act upstream of or within T cell differentiation; negative regulation of leukocyte chemotaxis; and negative regulation of tumor necrosis factor production. Predicted to be located in plasma membrane. Predicted to be integral component of plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | GPR18 |
| Official Name | G protein-coupled receptor 18 [Source:HGNC Symbol;Acc:HGNC:4472] |
| Ensembl ID | ENSG00000125245 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor 18 |
| Synonyms | DRV2, G protein-coupled receptor 18, LOC686964 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GPR18 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- 7 transmembrane receptor (rhodopsin family)
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the GPR18 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- insulin-dependent diabetes mellitus
- sepsis
- androgenic alopecia
- reperfusion injury
- infection by bacteria
role in cell
- apoptosis
- differentiation
- chemotaxis
- growth
- number
- quantity
- cellular infiltration by
- phagocytosis by
- efferocytosis by
- phagocytosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GPR18 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- positive regulation of Rho protein signal transduction
- negative regulation of leukocyte chemotaxis
- G-protein coupled receptor signaling pathway
- CD8-positive, gamma-delta intraepithelial T cell differentiation
- phospholipase C-activating G-protein coupled receptor signaling pathway
- negative regulation of tumor necrosis factor production
- CD8-positive, alpha-beta intraepithelial T cell differentiation
Cellular Component
Where in the cell the gene product is active
- cytoplasmic vesicle membrane
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity