SERPINB5 Gene Summary [Human]
Predicted to enable serine-type endopeptidase inhibitor activity. Predicted to be involved in negative regulation of endopeptidase activity. Predicted to act upstream of or within several processes, including extracellular matrix organization; prostate gland morphogenesis; and regulation of epithelial cell proliferation. Located in cytoplasm. Biomarker of hepatocellular carcinoma. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SERPINB5 |
| Official Name | serpin family B member 5 [Source:HGNC Symbol;Acc:HGNC:8949] |
| Ensembl ID | ENSG00000206075 |
| Bio databases IDs | |
| Aliases | serpin family B member 5, protease inhibitor 5 (maspin) |
| Synonyms | 1110036M19RIK, Maspin, ovalbumin, PI-5, serine (or cysteine) peptidase inhibitor, clade B, member 5, serpin family B member 5, Spi7 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SERPINB5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- SERine Proteinase INhibitors (serpin) family
- protein binding
- Serpin (serine protease inhibitor)
- reactive serpin loop
Pathways
Biological processes and signaling networks where the SERPINB5 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- cancer
- metastasis
- epithelial cancer
- epithelial neoplasia
- rheumatoid arthritis
- plaque psoriasis
- lung cancer
- pancreatic ductal adenocarcinoma
- pancreatic epithelial cancer
role in cell
- expression in
- cell viability
- growth
- apoptosis
- phosphorylation in
- proliferation
- cell death
- morphology
- binding in
- activity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- cornified envelope
- Cytoplasm
- cell surface
- basal compartment
- Nucleus
- Mitochondria
- cytosol
- sarcoplasm
- basement membrane
- cytoplasmic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SERPINB5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- morphogenesis of an epithelium
- extracellular matrix organization
- negative regulation of endopeptidase activity
- regulation of epithelial cell proliferation
- prostate gland morphogenesis
Cellular Component
Where in the cell the gene product is active
- extracellular space
- cornified envelope
- sarcoplasm
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- serine-type endopeptidase inhibitor activity
- protein binding