GRK4 Gene Summary [Human]
This gene encodes a member of the guanine nucleotide-binding protein (G protein)-coupled receptor kinase subfamily of the Ser/Thr protein kinase family. The protein phosphorylates the activated forms of G protein-coupled receptors thus initiating its deactivation. This gene has been linked to both genetic and acquired hypertension. Several transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Nov 2013]
Details
| Type | Protein Coding |
| Official Symbol | GRK4 |
| Official Name | G protein-coupled receptor kinase 4 [Source:HGNC Symbol;Acc:HGNC:4543] |
| Ensembl ID | ENSG00000125388 |
| Bio databases IDs | |
| Aliases | G protein-coupled receptor kinase 4 |
| Synonyms | A830025H08Rik, GPRK2L, GPRK4, G protein-coupled receptor kinase 4, GRK, GRK2, GRK4a, IT11 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GRK4 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein serine/threonine kinase
- Protein kinase (unclassified specificity)
- catalytic domain
- Protein tyrosine and serine/threonine kinase
- RGS homology domain
- Regulator of G protein signaling (RGS) domain superfamily
- protein binding
- Protein kinase domain
- kinase
- Regulator of G protein signaling domain
- Serine/Threonine protein kinases, catalytic domain
- kinase domain
- Protein Kinases, catalytic domain
- Extension to Ser/Thr-type protein kinases
- alcohol group acceptor phosphotransferase
- rhodopsin kinase
- Tyrosine kinase, catalytic domain
Pathways
Biological processes and signaling networks where the GRK4 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- alcohol use disorder
- hyperalgesia
- venous thromboembolism
role in cell
- activation in
- survival
- expression in
- stabilization in
- phosphorylation in
- stabilization
- binding in
- degradation in
- G2/M phase transition
- turnover in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- somatodendritic region
- cellular membrane
- Golgi Apparatus
- Mitochondria
- cytosol
- acrosome
- intercalated disks
- Z line
- cytoplasmic vesicles
- membrane rafts
- perikaryon
- dendrites
- detergent-soluble fraction
- cytosolic fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GRK4 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- regulation of G-protein coupled receptor protein signaling pathway
- protein phosphorylation
- receptor internalization
- regulation of signal transduction
- regulation of rhodopsin mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cell cortex
- cytosol
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- rhodopsin kinase activity
- ATP binding
- protein kinase activity