MBOAT7 Gene Summary [Human]
This gene encodes a member of the membrane-bound O-acyltransferases family of integral membrane proteins that have acyltransferase activity. The encoded protein is a lysophosphatidylinositol acyltransferase that has specificity for arachidonoyl-CoA as an acyl donor. This protein is involved in the reacylation of phospholipids as part of the phospholipid remodeling pathway known as the Land cycle. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2009]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | MBOAT7 |
| Official Name | membrane bound O-acyltransferase domain containing 7 [Source:HGNC Symbol;Acc:HGNC:15505] |
| Ensembl ID | ENSG00000125505 |
| Bio databases IDs | |
| Aliases | membrane bound O-acyltransferase domain containing 7, lysophosphatidylinositol acyltransferase, lysophospholipid acyltransferase 7 |
| Synonyms | 5730589L02Rik, BB1, hMBOA-7, LENG4, LOC100909580, LPIAT, LPIAT1, LPLAT, LPLAT11, LPLAT 7, LRC4, MBOA7, Mboat7l1, membrane bound O-acyltransferase domain containing 7, m-mboa-7, MRT57, OACT7, RGD1306945 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MBOAT7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- 1-acylglycerol-3-phosphate O-acyltransferase
- 2-acylglycerol-3-phosphate O-acyltransferase
- MBOAT, membrane-bound O-acyltransferase family
- enzyme
- protein binding
- O-acyltransferase
- Non-amino-acyl group acyltransferase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- nonalcoholic fatty liver disease
- hepatic steatosis
- autosomal recessive mental retardation type 57
- organismal death
- hypoplasia
- hereditary disorder
- KRAS G12X activating mutation positive non-small cell lung cancer
- tumorigenesis
- hydrocephalus
role in cell
- production in
- proliferation
- apoptosis
- migration
- abnormal morphology
- differentiation
- damage
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- endoplasmic reticulum mitochondria contact site
- cellular membrane
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MBOAT7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- ventricular system development
- layer formation in cerebral cortex
- phosphatidylcholine acyl-chain remodeling
- phosphatidylinositol biosynthetic process
- phosphatidylinositol acyl-chain remodeling
- regulation of triglyceride metabolic process
- lipid modification
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- membrane
- ER-mitochondrion membrane contact site
- endoplasmic reticulum
Molecular Function
What the gene product does at the molecular level
- 1-acylglycerol-3-phosphate O-acyltransferase activity
- lysophospholipid acyltransferase activity
- protein binding
- O-acyltransferase activity
- 2-acylglycerol-3-phosphate O-acyltransferase activity