RTN2 Gene Summary [Human]
This gene belongs to the family of reticulon encoding genes. Reticulons are associated with the endoplasmic reticulum, and are involved in neuroendocrine secretion or in membrane trafficking in neuroendocrine cells. Reticulon proteins also play an important role in the replication of positive-strand RNA (ssRNA) viruses. Mutations at this locus have been associated with autosomal dominant spastic paraplegia-12. [provided by RefSeq, Aug 2020]
Details
| Type | Protein Coding |
| Official Symbol | RTN2 |
| Official Name | reticulon 2 [Source:HGNC Symbol;Acc:HGNC:10468] |
| Ensembl ID | ENSG00000125744 |
| Bio databases IDs | |
| Aliases | reticulon 2, NSP-like protein 1, Neuroendocrine-specific protein-like 1 |
| Synonyms | HMNR11, MMS10-P, Ms10p, NSP2, NSPL1, NSPLI, reticulon 2, reticulon 2 (Z-band associated protein), RTN2-B, SPG12 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human RTN2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Reticulon
- lumenal/extracellular domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal dominant spastic paraplegia type 12
- schizophrenia
- Huntington disease
- spastic paraplegia
- infection by HIV-1
role in cell
- formation
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- sarcoplasmic reticulum
- Endoplasmic Reticulum
- intermediate filaments
- endoplasmic reticulum membrane
- Z line
- transverse tubules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human RTN2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intracellular protein transmembrane transport
- gene expression
- regulation of glucose import
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- T-tubule
- Z disc
- intermediate filament
- endoplasmic reticulum
- terminal cisterna
- cell surface
- sarcoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- protein binding