Rtn2 Gene Summary [Mouse]
Acts upstream of or within gene expression; intracellular protein transmembrane transport; and regulation of D-glucose import. Located in several cellular components, including T-tubule; Z disc; and terminal cisterna. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; nervous system; and sensory organ. Human ortholog(s) of this gene implicated in hereditary spastic paraplegia 12. Orthologous to human RTN2 (reticulon 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | Rtn2 |
| Official Name | reticulon 2 (Z-band associated protein) [Source:MGI Symbol;Acc:MGI:107612] |
| Ensembl ID | ENSMUSG00000030401 |
| Bio databases IDs | |
| Aliases | reticulon 2 (Z-band associated protein) |
| Synonyms | HMNR11, MMS10-P, Ms10p, NSP2, NSPL1, NSPLI, reticulon 2, reticulon 2 (Z-band associated protein), RTN2-B, SPG12 |
| Species | Mouse, Mus musculus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in mouse Rtn2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Reticulon
- lumenal/extracellular domain
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal dominant spastic paraplegia type 12
- schizophrenia
- Huntington disease
- spastic paraplegia
- infection by HIV-1
role in cell
- formation
- formation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cell surface
- sarcoplasmic reticulum
- Endoplasmic Reticulum
- intermediate filaments
- endoplasmic reticulum membrane
- Z line
- transverse tubules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the mouse Rtn2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- intracellular protein transmembrane transport
- gene expression
- regulation of glucose import
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- T-tubule
- Z disc
- intermediate filament
- endoplasmic reticulum
- terminal cisterna
- cell surface
- sarcoplasmic reticulum membrane
Molecular Function
What the gene product does at the molecular level
- protein binding