F2RL3 Gene Summary [Human]
This gene encodes a member of the protease-activated receptor subfamily, part of the G-protein coupled receptor 1 family of proteins. The encoded receptor is proteolytically processed to reveal an extracellular N-terminal tethered ligand that binds to and activates the receptor. This receptor plays a role in blood coagulation, inflammation and response to pain. Hypomethylation at this gene may be associated with lung cancer in human patients. [provided by RefSeq, Sep 2016]
Details
| Type | Protein Coding |
| Official Symbol | F2RL3 |
| Official Name | F2R like thrombin or trypsin receptor 3 [Source:HGNC Symbol;Acc:HGNC:3540] |
| Ensembl ID | ENSG00000127533 |
| Bio databases IDs | |
| Aliases | F2R like thrombin or trypsin receptor 3, proteinase-activated receptor-4 |
| Synonyms | F2R like thrombin or trypsin receptor 3, PAR4 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human F2RL3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- extracellular domain
- intracellular loop
- thrombin receptor
- Cholecystokinin A receptor, N-terminal
- protease binding
- 7 transmembrane receptor (rhodopsin family)
- cleavage site
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the F2RL3 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- embolism
- pulmonary embolism
- pruritus
- cardiac injury
- bleeding
- idiopathic pulmonary fibrosis
- diabetic nephropathy
role in cell
- expression in
- activation
- number
- apoptosis
- phosphorylation in
- migration
- aggregation
- accumulation
- response
- release
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- Extracellular Space
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human F2RL3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- platelet dense granule organization
- thrombin receptor signaling pathway
- positive regulation of Rho protein signal transduction
- signal transduction
- response to wounding
- blood coagulation
- positive regulation of release of sequestered calcium ion into cytosol
- phospholipase C-activating G-protein coupled receptor signaling pathway
- platelet activation
- platelet aggregation
Cellular Component
Where in the cell the gene product is active
- extracellular region
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- thrombin receptor activity
- protease binding