CDC42EP1 Gene Summary [Human]
CDC42 is a member of the Rho GTPase family that regulates multiple cellular activities, including actin polymerization. The protein encoded by this gene is a CDC42 binding protein that mediates actin cytoskeleton reorganization at the plasma membrane. This protein is secreted and is primarily found in bone marrow. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | CDC42EP1 |
| Official Name | CDC42 effector protein 1 [Source:HGNC Symbol;Acc:HGNC:17014] |
| Ensembl ID | ENSG00000128283 |
| Bio databases IDs | |
| Aliases | CDC42 effector protein 1, 55 kDa bone marrow stromal/endothelial cell protein, serum constituent protein, binder of Rho GTPases 5 |
| Synonyms | 1810058K22Rik, BORG5, CDC42 effector protein 1, CEP1, haemoNECTIN, HEMONECTIN, MSE55 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human CDC42EP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cdc42 effector
- protein binding
Pathways
Biological processes and signaling networks where the CDC42EP1 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Extracellular Space
- Cytoplasm
- cellular membrane
- actin filaments
- cytosol
- membrane ruffles
- plasma
- lamellipodia
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human CDC42EP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of cell shape
- positive regulation of pseudopodium assembly
- positive regulation of actin filament polymerization
- Rho protein signal transduction
Cellular Component
Where in the cell the gene product is active
- adherens junction
- cytoskeleton
- focal adhesion
- cytoplasm
- cytosol
- endomembrane system
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- small GTPase binding