PRKRIP1 Gene Summary [Human]
Predicted to enable double-stranded RNA binding activity; protein kinase binding activity; and protein kinase inhibitor activity. Involved in renal system process. Located in extracellular exosome. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Processed Transcript |
| Official Symbol | PRKRIP1 |
| Official Name | PRKR interacting protein 1 [Source:HGNC Symbol;Acc:HGNC:21894] |
| Ensembl ID | ENSG00000128563 |
| Bio databases IDs | |
| Aliases | PRKR interacting protein 1, likely ortholog of mouse C114 dsRNA-binding protein, KRAB box domain containing 3 |
| Synonyms | 8430424D23Rik, C114, KRBOX3, PRKR interacting protein 1, Prkr interacting protein 1 (IL11 inducible) |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PRKRIP1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- protein kinase inhibitor activity
- double-stranded RNA binding
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nucleoli
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PRKRIP1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA splicing
- mRNA processing
- negative regulation of protein kinase activity
- renal system process
- negative regulation of phosphorylation
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- spliceosomal complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- protein binding
- double-stranded RNA binding
- protein kinase inhibitor activity