DCUN1D1 Gene Summary [Human]
Enables cullin family protein binding activity. Involved in positive regulation of protein neddylation and regulation of protein ubiquitination. Located in cytosol and nucleoplasm. Part of ubiquitin ligase complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | DCUN1D1 |
| Official Name | defective in cullin neddylation 1 domain containing 1 [Source:HGNC Symbol;Acc:HGNC:18184] |
| Ensembl ID | ENSG00000043093 |
| Bio databases IDs | |
| Aliases | defective in cullin neddylation 1 domain containing 1, squamous cell carcinoma related oncogene |
| Synonyms | DCN1, DCNL1, DCUN1L1, defective in cullin neddylation 1 domain containing 1, LOC100912352, LOC102553014, pTes3, RP42, SCCRO, SCRO, Tes3 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human DCUN1D1 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- UBA domain-like superfamily
- UBA-like domain
- ubiquitin binding domain
- protein binding
- Cullin binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- prostatic adenocarcinoma
- prostate cancer
- systemic juvenile idiopathic arthritis
- neoplastic cell transformation
- epithelial cancer
- androgenic alopecia
role in cell
- migration
- proliferation
- neddylation in
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human DCUN1D1 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein neddylation
- regulation of protein ubiquitination
- positive regulation of protein neddylation
- regulation of protein neddylation
Cellular Component
Where in the cell the gene product is active
- nucleus
- ubiquitin ligase complex
- cytoplasm
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- small conjugating protein binding
- ubiquitin conjugating enzyme binding
- protein binding