TXNDC17 Gene Summary [Human]
Enables peroxidase activity and protein-disulfide reductase (NAD(P)) activity. Involved in tumor necrosis factor-mediated signaling pathway. Located in cytosol. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | TXNDC17 |
| Official Name | thioredoxin domain containing 17 [Source:HGNC Symbol;Acc:HGNC:28218] |
| Ensembl ID | ENSG00000129235 |
| Bio databases IDs | |
| Aliases | thioredoxin domain containing 17, thioredoxin (Trx)-related protein, 14 kDa |
| Synonyms | 4831443O22Rik, D11Ertd672e, thioredoxin domain containing 17, TRP14, TXNL5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TXNDC17 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- peroxidase
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- enzyme
- protein binding
- protein-disulfide reductase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- obesity
- ceruletide-induced acute pancreatitis
role in cell
- cohesion
- cohesion in
- reduction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TXNDC17 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- tumor necrosis factor-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- extracellular vesicular exosome
- cytosol
Molecular Function
What the gene product does at the molecular level
- peroxidase activity
- protein binding
- protein-disulfide reductase activity