TRIM5 Gene Summary [Human]
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. The protein forms homo-oligomers via the coilel-coil region and localizes to cytoplasmic bodies. It appears to function as a E3 ubiquitin-ligase and ubiqutinates itself to regulate its subcellular localization. It may play a role in retroviral restriction. Multiple alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Dec 2009]
Details
| Type | Protein Coding |
| Official Symbol | TRIM5 |
| Official Name | tripartite motif containing 5 [Source:HGNC Symbol;Acc:HGNC:16276] |
| Ensembl ID | ENSG00000132256 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 5, tripartite motif protein TRIM5, tripartite motif protein TRIM |
| Synonyms | LOC101927800, RGD1304579, RNF88, TRIM5alpha, tripartite motif-containing 5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM5 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription co-activator
- protein kinase binding
- signaling receptor activity
- SPRY domain
- zinc finger of C3HC4-type, RING
- protein binding activity, bridging
- enzyme
- Ring finger domain
- protein binding
- identical protein binding
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- Ring finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- ubiquitin-protein transferase activity
- protein homodimerization
- B-box zinc finger
- Outer membrane protein (OmpH-like)
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- infection
- multiple sclerosis
- coronary artery disease
- glioma
- glioma formation
- peripheral arterial disease
- oligoastrocytoma
- organismal death
- neuroblastoma
- neuroblastoma formation
role in cell
- autophagy by
- activation in
- signaling in
- replication in
- innate immune response in
- ubiquitination in
- retrotransposition in
- restriction in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- omegasome
- cytoplasmic mRNA processing body
- granules
- cytoplasmic aggregates
- cytosol
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM5 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein localization
- protein polyubiquitination
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- positive regulation of MAPK cascade
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of autophagy
- regulation of viral entry into host cell
- negative regulation of viral entry into host cell
- positive regulation of transcription, DNA-dependent
- activation of innate immune response
- autophagy
- innate immune response
- defense response to virus
- protein K63-linked ubiquitination
- regulation of lipopolysaccharide-mediated signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cytoplasmic mRNA processing body
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- ubiquitin-protein ligase activity
- protein kinase binding
- identical protein binding
- zinc ion binding
- protein homodimerization activity
- protein binding
- transcription coactivator activity
- protein binding, bridging