TRIM22 Gene Summary [Human]
The protein encoded by this gene is a member of the tripartite motif (TRIM) family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. The protein is involved in innate immunity against different DNA and RNA viruses. [provided by RefSeq, Oct 2021]
Details
| Type | Protein Coding |
| Official Symbol | TRIM22 |
| Official Name | tripartite motif containing 22 [Source:HGNC Symbol;Acc:HGNC:16379] |
| Ensembl ID | ENSG00000132274 |
| Bio databases IDs | |
| Aliases | tripartite motif containing 22 |
| Synonyms | GPSTAF50, RNF94, STAF50, STIMULATED TRANS-ACTING FACTOR (50 KDA), tripartite motif containing 22 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TRIM22 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- transcription co-activator
- protein kinase binding
- SPRY domain
- ubiquitin protein ligase activity
- zinc finger of C3HC4-type, RING
- transcription co-repressor
- protein binding activity, bridging
- F-type ATP synthase, membrane subunit b
- Ring finger domain
- protein binding
- identical protein binding
- PLC-beta C terminal
- B-box-type zinc finger superfamily
- RING-type zinc-finger
- RING finger (Really Interesting New Gene) domain and U-box domain superfamily
- Ring finger
- B-box zinc finger
- Zinc finger, C3HC4 type (RING finger)
- zinc-RING finger domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- glioma
- psoriasis
- multiple sclerosis
- liver cancer
- hyperzincemia and hypercalprotectinemia autoinflammatory syndrome
- androgenic alopecia
- Hutchinson-Gilford progeria syndrome
- glioma formation
- low-grade glioma
- non-small cell lung cancer
role in cell
- apoptosis
- growth
- expression in
- phosphorylation in
- colony formation
- proliferation
- production in
- transcription in
- interaction in
- autophagy by
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Golgi Apparatus
- cytosol
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TRIM22 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of protein localization
- protein polyubiquitination
- positive regulation of I-kappaB kinase/NF-kappaB cascade
- regulation of transcription, DNA-dependent
- positive regulation of defense response to virus by host
- response to virus
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of NF-kappaB transcription factor activity
- positive regulation of autophagy
- immune response
- negative regulation of transcription, DNA-dependent
- regulation of viral entry into host cell
- positive regulation of transcription, DNA-dependent
- innate immune response
- defense response to virus
- protein K63-linked ubiquitination
Cellular Component
Where in the cell the gene product is active
- nucleus
- nuclear body
- cytoplasm
- nuclear speck
- Cajal body
- cytosol
- Golgi apparatus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- zinc ion binding
- identical protein binding
- protein binding
- protein homodimerization activity
- transcription coactivator activity
- transcription corepressor activity
- protein binding, bridging