SLC38A2 Gene Summary [Human]
Enables neutral amino acid:sodium symporter activity. Involved in several processes, including amino acid transport; cellular response to arsenite(3-); and positive regulation of RNA splicing. Located in cytoplasm and plasma membrane. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | SLC38A2 |
| Official Name | solute carrier family 38 member 2 [Source:HGNC Symbol;Acc:HGNC:13448] |
| Ensembl ID | ENSG00000134294 |
| Bio databases IDs | |
| Aliases | solute carrier family 38 member 2 |
| Synonyms | 5033402L14Rik, ATA2, Atrc2, mKIAA1382, PRO1068, SAT2, SNAT2, solute carrier family 38 member 2, solute carrier family 38, member 2, System A |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SLC38A2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- neutral amino acid:sodium symporter
- alanine:sodium symporter
- glutamine transporter
- sodium:amino acid transporter
- protein binding
- Solute carrier families 5 and 6-like; solute binding domain
- acidic amino acid transporter
- proline:sodium symporter
- serine transporter
- amino acid transporter
- transporter
- neutral amino acid transporter
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- epithelial cancer
- hepatocellular carcinoma
- liver cancer
regulates
- MTOR
- glycine
- 2-(methylamino)isobutyric acid
- L-glutamine
- L-proline
- amino acids
- neutral amino acid
- glutamine
- asparagine
- L-methionine
role in cell
- activation in
- endoplasmic reticulum stress response
- response by
- lipotoxicity in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- Cytoplasm
- Mitochondria
- sarcolemma
- microsomal membrane
- brush border
- perikaryon
- axons
- dendrites
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SLC38A2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to muscle activity
- glycine betaine transport
- cellular response to amino acid starvation
- positive regulation of RNA splicing
- regulation of cellular response to stress
- female pregnancy
- cerebral cortex development
- amino acid transport
- amino acid transmembrane transport
- glutamine transport
- neurotransmitter transport
- cellular response to mechanical stimulus
- alanine transport
- positive regulation of gene expression
- neutral amino acid transport
- L-serine transport
- sodium ion transmembrane transport
- proline transport
- acidic amino acid transport
- amino acid import
Cellular Component
Where in the cell the gene product is active
- dendrite
- brush border
- cytoplasm
- sarcolemma
- neuronal cell body
- plasma membrane
- axon
Molecular Function
What the gene product does at the molecular level
- protein binding
- L-glutamine transmembrane transporter activity
- neutral amino acid:sodium symporter activity
- sodium:amino acid symporter activity
- L-serine transmembrane transporter activity
- acidic amino acid transmembrane transporter activity
- amino acid transmembrane transporter activity
- proline:sodium symporter activity
- alanine:sodium symporter activity