CYP2J2
CYP2J2 Gene Summary
This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and is thought to be the predominant enzyme responsible for epoxidation of endogenous arachidonic acid in cardiac tissue. Multiple transcript variants have been found for this gene. [provided by RefSeq, Jan 2016]
Details
| Type | Protein Coding |
| Official Symbol | CYP2J2 |
| Official Name | cytochrome P450 family 2 subfamily J member 2 [Source:HGNC Symbol;Acc:HGNC:2634] |
| Ensembl ID | ENSG00000134716 |
| Bio databases IDs | |
| Aliases | cytochrome P450 family 2 subfamily J member 2 |
| Synonyms | CPJ2,CYPIIJ2,cytochrome P450 family 2 subfamily J member 2 |
| Species | Human, Homo sapiens |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cytochrome P450 (CYP) superfamily
- Cytochrome P450
- arachidonic acid 11,12-epoxygenase
- arachidonic acid 14,15-epoxygenase
- unspecific monooxygenase
- monooxygenase
- isomerase
- enzyme
- paired donor oxygen oxidoreductase
- arachidonic acid epoxygenase
Pathways
Biological processes and signaling networks where the CYP2J2 gene plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
binds
- POU2F1
- NDUFB8
- JUN
- USP22
- ECPAS
- VPS28
- HNF4A
- VDR
- NELFB
- NDUFB5
disease
- liver cancer
- epithelial cancer
- proteinuria
- chronic obstructive pulmonary disease
- keratocystic odontogenic tumor
- keratocystic odontogenic tumors
- hepatitis B virus-related hepatocellular carcinoma
- cardiac hypertrophy
- diabetic nephropathy
- rotator cuff injury
regulated by
- LDL
- pirinixic acid
- JUN
- Influenza A virus (A/Udon/307/72 (H3N2))
- dexamethasone
- flunarizine
- TNF
- bacterial lipopolysaccharides
- SB203580
- FOSL2
regulates
- VCAM1
- ICAM1
- IL1B
- TNF
- D-glucose
- IL6
- PPARG
- BCL2
- AKT
- proinsulin
role in cell
- activation in
- apoptosis
- proliferation
- expression in
- quantity
- cellular infiltration by
- adhesion
- migration
- invasion
- binding in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the CYP2J2 gene, providing context for its role in the cell.
BIOLOGICAL PROCESS
Functions and activities the gene product is involved in
- organic acid metabolic process
- epoxygenase P450 pathway
- icosanoid metabolic process
- xenobiotic metabolic process
- regulation of heart contraction
- linoleic acid metabolic process
- fatty acid metabolic process
CELLULAR COMPONENT
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- extracellular vesicular exosome
- cytoplasm
- intracellular membrane-bounded organelle
MOLECULAR FUNCTION
What the gene product does at the molecular level
- oxidoreductase activity, acting on paired donors, with incorporation or reduction of molecular oxygen, reduced flavin or flavoprotein as one donor, and incorporation of one atom of oxygen
- arachidonic acid epoxygenase activity
- iron ion binding
- arachidonic acid 11,12-epoxygenase activity
- monooxygenase activity
- arachidonic acid 14,15-epoxygenase activity
- isomerase activity
- linoleic acid epoxygenase activity
- heme binding