NELFB Gene Summary [Human]
NELFB is a subunit of negative elongation factor (NELF), which also includes NELFA (WHSC2; MIM 606026), either NELFC or NELFD (TH1L; MIM 605297), and NELFE (RDBP; MIM 154040). NELF acts with DRB sensitivity-inducing factor (DSIF), a heterodimer of SPT4 (SUPT4H1; MIM 603555) and SPT5 (SUPT5H; MIM 602102), to cause transcriptional pausing of RNA polymerase II (see MIM 180660) (Narita et al., 2003 [PubMed 12612062]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | NELFB |
| Official Name | negative elongation factor complex member B [Source:HGNC Symbol;Acc:HGNC:24324] |
| Ensembl ID | ENSG00000188986 |
| Bio databases IDs | |
| Aliases | negative elongation factor complex member B |
| Synonyms | A730008L03RIK, COBRA1, negative elongation factor complex member B, RGD1307832 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human NELFB often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Cofactor of BRCA1 (COBRA1)
- protein binding
Pathways
Biological processes and signaling networks where the NELFB gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
role in cell
- expression in
- apoptosis
- proliferation
- differentiation
- cell cycle progression
- G0/S phase transition
- JQ1-sensitivity
- decondensation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
- cytosol
- mitochondrial outer membrane
- nucleoplasm
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human NELFB gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- cell proliferation
- negative regulation of transcription elongation from RNA polymerase II promoter
- stem cell differentiation
- negative regulation of stem cell differentiation
Cellular Component
Where in the cell the gene product is active
- nucleus
- NELF complex
- cytoplasm
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- RNA binding
- protein binding