ELP2 Gene Summary [Human]
The protein encoded by this gene is a core subunit of the elongator complex, a histone acetyltransferase complex that associates with RNA polymerase II. In addition to histone acetylation, the encoded protein effects transcriptional elongation and may help remodel chromatin. [provided by RefSeq, May 2016]
Details
| Type | Protein Coding |
| Official Symbol | ELP2 |
| Official Name | elongator acetyltransferase complex subunit 2 [Source:HGNC Symbol;Acc:HGNC:18248] |
| Ensembl ID | ENSG00000134759 |
| Bio databases IDs | |
| Aliases | elongator acetyltransferase complex subunit 2 |
| Synonyms | elongator acetyltransferase complex subunit 2, Epl2, MRT58, SHINC-2, Stat3ip1, STATIP1, StIP, STIP1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ELP2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein kinase binding
- WD40 repeats
- WD domain, G-beta repeat
- enzyme binding
- WD40
- protein binding
- enzyme regulator activity
- protease activator
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- autosomal recessive mental retardation type 58
- hereditary disorder
- major depression
- autosomal recessive nonsyndromic mental retardation
- microcephaly
- covid-19 death
role in cell
- expression in
- cell death
- pyroptosis
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytosol
- nucleoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ELP2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of translation
- regulation of JAK-STAT cascade
- tRNA wobble uridine modification
- regulation of transcription from RNA polymerase II promoter
- transcription elongation from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- transcription elongation factor complex
- cytoplasm
- Elongator holoenzyme complex
- cytosol
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein kinase binding
- RNA polymerase II core binding