C5ar2 Gene Summary [Rat]
Predicted to enable G protein-coupled receptor activity and complement component C5a receptor activity. Predicted to be involved in several processes, including complement receptor mediated signaling pathway; negative regulation of neutrophil chemotaxis; and regulation of cytokine production. Predicted to be located in apical part of cell and basal plasma membrane. Predicted to be active in plasma membrane. Orthologous to human C5AR2 (complement C5a receptor 2). [provided by Alliance of Genome Resources, Jul 2025]
Details
| Type | Protein Coding |
| Official Symbol | C5ar2 |
| Official Name | complement component 5a receptor 2 [Source:RGD Symbol;Acc:1303027] |
| Ensembl ID | ENSRNOG00000049028 |
| Bio databases IDs | |
| Aliases | complement component 5a receptor 2 |
| Synonyms | C5L2, complement C5a receptor 2, complement component 5a receptor 2, E030029A11RIK, GPF77, GPR77 |
| Species | Rat, Rattus norvegicus |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in rat C5ar2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- Cholecystokinin A receptor, N-terminal
- intracellular domain
- 7 transmembrane receptor (rhodopsin family)
- serine threonine rich domain
- protein binding
- seven-transmembrane G protein-coupled receptor superfamily
Pathways
Biological processes and signaling networks where the C5ar2 gene in rat plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- acute septic peritonitis
- airway hyperresponsiveness
- multiple system atrophy
- multiple organ failure
- sepsis
- lymphopenia
- edema
- epidermolysis bullosa acquisita
- pathogenesis
role in cell
- quantity
- molecular cleavage in
- activation
- migration
- presence
- formation
- chemotaxis
- degranulation
- number
- cell viability
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cell surface
- intracellular space
- apical compartment
- cellular membrane
- basal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the rat C5ar2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of interleukin-6 production
- chemotaxis
- inflammatory response
- negative regulation of neutrophil chemotaxis
- phospholipase C-activating G-protein coupled receptor signaling pathway
- complement receptor mediated signaling pathway
- negative regulation of tumor necrosis factor production
- regulation of interleukin-8 production
- elevation of cytosolic calcium ion concentration
Cellular Component
Where in the cell the gene product is active
- basal plasma membrane
- apical part of cell
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- G-protein coupled receptor activity
- complement component C5a receptor activity
- protein binding