ARHGAP32 Gene Summary [Human]
RICS is a neuron-associated GTPase-activating protein that may regulate dendritic spine morphology and strength by modulating Rho GTPase (see RHOA; MIM 165390) activity (Okabe et al., 2003 [PubMed 12531901]).[supplied by OMIM, Mar 2008]
Details
| Type | Protein Coding |
| Official Symbol | ARHGAP32 |
| Official Name | Rho GTPase activating protein 32 [Source:HGNC Symbol;Acc:HGNC:17399] |
| Ensembl ID | ENSG00000134909 |
| Bio databases IDs | |
| Aliases | Rho GTPase activating protein 32 |
| Synonyms | 3426406O18RIK, GC-GAP, GRIT, mKIAA0712, p200RhoGAP, p250GAP, PX-RICS, Rho GTPase activating protein 32, RICS |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ARHGAP32 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- RhoGAP domain
- Family of unknown function (DUF5585)
- catalytic domain
- GTPase activator
- The Phox Homology domain, a phosphoinositide binding module
- protein binding
- GTPase Activating Protein domain
- GTPase-activator protein for Rho-like GTPases
- RhoGAP
- TrkA binding domain
- Src Homology 3 domain superfamily
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- seizures
- breast cancer
- Huntington disease
- pemphigus foliaceus
- refractive error
- cerebral aneurysm
- systemic lupus erythematosus
- infection by HIV-1
role in cell
- proliferation
- differentiation
- growth
- formation
- migration
- cell focus formation
- transformation
- migration by
- elongation
- outgrowth
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- postsynaptic density (PSD) fractions
- glutaminergic synapse
- fibrillar center
- cell periphery
- actin cytoskeleton
- cell cortex
- Golgi Apparatus
- cytosol
- nucleoplasm
- dendritic spines
- nerve ending
- postsynaptic density
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ARHGAP32 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- regulation of small GTPase mediated signal transduction
- small GTPase mediated signal transduction
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- postsynaptic density
- cell cortex
- dendritic spine
- actin cytoskeleton
- cytosol
- Golgi apparatus
- endosome membrane
- Golgi membrane
- fibrillar center
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- GTPase activator activity