SENP7 Gene Summary [Human]
The reversible posttranslational modification of proteins by the addition of small ubiquitin-like SUMO proteins (see SUMO1; MIM 601912) is required for many cellular processes. SUMO-specific proteases, such as SENP7, process SUMO precursors to generate a C-terminal diglycine motif required for the conjugation reaction. They also display isopeptidase activity for deconjugation of SUMO-conjugated substrates (Lima and Reverter, 2008 [PubMed 18799455]).[supplied by OMIM, Jun 2009]
Details
| Type | Protein Coding |
| Official Symbol | SENP7 |
| Official Name | SUMO specific peptidase 7 [Source:HGNC Symbol;Acc:HGNC:30402] |
| Ensembl ID | ENSG00000138468 |
| Bio databases IDs | |
| Aliases | SUMO specific peptidase 7 |
| Synonyms | 2410152H17Rik, 2810413I22RIK, 2900036C23RIK, 6030449K19Rik, SSP2, SUMO1/sentrin specific peptidase 7, SUMO specific peptidase 7, SUSP2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SENP7 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- cysteine endopeptidase
- catalytic domain
- Ulp1 protease family, C-terminal catalytic domain
- peptidase
- protein binding
- ubiquitin-like-specific protease
Pathways
Biological processes and signaling networks where the SENP7 gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- myeloproliferative disorder
- COVID-19
- breast cancer
- dermatological disorder
- actinic keratosis
role in cell
- expression in
- proliferation
- degradation in
- production in
- size
- number
- quantity
- oxidative phosphorylation in
- glycolysis in
- sumoylation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- Cytoplasm
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SENP7 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein desumoylation
- proteolysis
Cellular Component
Where in the cell the gene product is active
- nucleus
- cytoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- SUMO-specific endopeptidase activity