PDCL Gene Summary [Human]
Phosducin-like protein is a putative modulator of heterotrimeric G proteins. The protein shares extensive amino acid sequence homology with phosducin, a phosphoprotein expressed in retina and pineal gland. Both phosducin-like protein and phosphoducin have been shown to regulate G-protein signaling by binding to the beta-gamma subunits of G proteins. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | PDCL |
| Official Name | phosducin like [Source:HGNC Symbol;Acc:HGNC:8770] |
| Ensembl ID | ENSG00000136940 |
| Bio databases IDs | |
| Aliases | phosducin like |
| Synonyms | 1200011E13Rik, Pdcl1, PhLP, PhLP1, phosducin-like |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human PDCL often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- binding protein
- Protein Disulfide Oxidoreductases and Other Proteins with a Thioredoxin fold
- Phosducin
- enzyme
- protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- Huntington disease
role in cell
- expression in
- phosphorylation in
- binding in
- migration
- tubulogenesis by
- disassembly
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- perinuclear region
- cytosol
- photoreceptor inner segments
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human PDCL gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- cell projection organization
- positive regulation of smoothened signaling pathway
- regulation of G-protein coupled receptor protein signaling pathway
- visual perception
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- cilium
- cytosol
Molecular Function
What the gene product does at the molecular level
- protein binding