GNG2 Gene Summary [Human]
This gene encodes one of the gamma subunits of a guanine nucleotide-binding protein. Such proteins are involved in signaling mechanisms across membranes. Various subunits forms heterodimers which then interact with the different signal molecules. [provided by RefSeq, Aug 2011]
Details
| Type | Protein Coding |
| Official Symbol | GNG2 |
| Official Name | G protein subunit gamma 2 [Source:HGNC Symbol;Acc:HGNC:4404] |
| Ensembl ID | ENSG00000186469 |
| Bio databases IDs | |
| Aliases | G protein subunit gamma 2 |
| Synonyms | 1110003P13RIK, G gamma2, G protein subunit gamma 2, G protein subunit γ 2, G protein γ 2, guanine nucleotide binding protein (G protein), gamma 2, guanine nucleotide binding protein (G protein), γ 2, HG3F1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human GNG2 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- GGL
- GTPase
- protein binding
- GGL domain
Pathways
Biological processes and signaling networks where the GNG2 gene in human plays a role, providing insight into its function and relevance in health or disease.
- AMPK Signaling
- Androgen Signaling
- Antiproliferative Role of Somatostatin Receptor 2
- Apelin Endothelial Signaling Pathway
- Apelin Muscle Signaling Pathway
- Cardiac β-adrenergic Signaling
- CCR3 Signaling in Eosinophils
- CCR5 Signaling in Macrophages
- CXCR4 Signaling
- Endocannabinoid Developing Neuron Pathway
- Ephrin B Signaling
- Ephrin Receptor Signaling
- fMLP Signaling in Neutrophils
- G Beta Gamma Signaling
- Glutamate Receptor Signaling
- Gαq Signaling
- IL-1 Signaling
- IL-8 Signaling
- Molecular Mechanisms of Cancer
- P2Y Purinergic Receptor Signaling Pathway
- Protein Kinase A Signaling
- Relaxin Signaling
- RhoGDI Signaling
- Sperm Motility
- Thrombin Signaling
- α-Adrenergic Signaling
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- chronic obstructive pulmonary disease
- lung carcinoma
- lung carcinoma process
- aortic valve calcification
- schizophrenia
- HER2 negative hormone receptor negative breast cancer
- cleft lip
- multiple sclerosis
- luminal A breast cancer
- essential thrombocythemia
role in cell
- phosphorylation in
- growth
- apoptosis
- proliferation
- binding in
- activation in
- binding
- formation
- sub-G1 phase
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- membrane fraction
- intracellular membranes
- cellular membrane
- Nucleus
- vesicles
- cytosol
- growth cone
- synapse
- specific granules
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human GNG2 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- fibroblast proliferation
- adenylate cyclase-activating dopamine receptor signaling pathway
- G-protein coupled receptor signaling pathway
- cellular response to catecholamine stimulus
- cellular response to prostaglandin E stimulus
Cellular Component
Where in the cell the gene product is active
- heterotrimeric G-protein complex
- extracellular vesicular exosome
- membrane
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- G-protein beta-subunit binding