FRS3 Gene Summary [Human]
This gene encodes a substrate for the fibroblast growth factor receptor. The encoded protein is found in the peripheral plasma membrane and links fibroblast growth factor receptor stimulation to activators of Ras. The encoded protein down-regulates extracellular regulated kinase 2 through direct binding. [provided by RefSeq, Jul 2013]
Details
| Type | Protein Coding |
| Official Symbol | FRS3 |
| Official Name | fibroblast growth factor receptor substrate 3 [Source:HGNC Symbol;Acc:HGNC:16970] |
| Ensembl ID | ENSG00000137218 |
| Bio databases IDs | |
| Aliases | fibroblast growth factor receptor substrate 3 |
| Synonyms | 4930417B13RIK, fibroblast growth factor receptor substrate 3, FRS2B, FRS2-beta, FRS2-β, SNT-2 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human FRS3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- PTB domain (IRS-1 type)
- protein binding
- phosphotyrosine binding domain
- Pleckstrin homology-like domain
- fibroblast growth factor receptor binding
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human FRS3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- signal transduction
- fibroblast growth factor receptor signaling pathway
Cellular Component
Where in the cell the gene product is active
- cytoplasm
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding
- transmembrane receptor protein tyrosine kinase adaptor activity
- fibroblast growth factor receptor binding