LHCGR Gene Summary [Human]
This gene encodes the receptor for both luteinizing hormone and choriogonadotropin. This receptor belongs to the G-protein coupled receptor 1 family, and its activity is mediated by G proteins which activate adenylate cyclase. Mutations in this gene result in disorders of male secondary sexual character development, including familial male precocious puberty, also known as testotoxicosis, hypogonadotropic hypogonadism, Leydig cell adenoma with precocious puberty, and male pseudohermaphtoditism with Leydig cell hypoplasia. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | LHCGR |
| Official Name | luteinizing hormone/choriogonadotropin receptor [Source:HGNC Symbol;Acc:HGNC:6585] |
| Ensembl ID | ENSG00000138039 |
| Bio databases IDs | |
| Aliases | luteinizing hormone/choriogonadotropin receptor |
| Synonyms | Gpcr19-rs1, HHG, LCGR, LGR2, LH/CG-R, LH-R, LH receptor, LHRHR, LSH-R, luteinizing hormone/choriogonadotropin receptor, ULG5 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LHCGR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- G-protein coupled receptor
- G-protein coupled peptide receptor
- endodomain
- extracellular domain
- hormone binding
- intracellular loop
- Cholecystokinin A receptor, N-terminal
- tyrosine sulfation motif
- ectodomain
- lutropin-choriogonadotropic hormone receptor
- Leucine rich repeat
- BspA type Leucine rich repeat region (6 copies)
- identical protein binding
- seven-transmembrane G protein-coupled receptor superfamily
- polypeptide hormone binding
- ATPase binding
- leucine-rich repeat
- transmembrane domain
- hinge domain
- extracellular loop
- protein-hormone receptor
- 7 transmembrane receptor (rhodopsin family)
- cytosolic tail domain
- cysteine rich domain
Pathways
Biological processes and signaling networks where the LHCGR gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- depressive disorder
- cancer
- lung cancer
- premenopausal primary breast cancer
- postmenopausal breast cancer
- colon cancer
- advanced breast cancer
- locally advanced prostate cancer
- prostatic adenocarcinoma
- adrenal cortex adenoma
role in cell
- proliferation
- binding
- apoptosis
- quantity
- formation
- spermatogenesis
- reorganization
- entrapment
- height
- function
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- detergent-soluble membrane fractions
- membrane fraction
- Cytoplasm
- cell surface
- Extracellular Space
- intracellular space
- perinuclear region
- cellular membrane
- Nucleus
- endosomes
- centrosome
- Endoplasmic Reticulum
- membrane compartment
- granules
- cytosol
- basal cytoplasm
- endoplasmic reticulum compartments
- sperm tail
- sperm head
- neurites
- perikaryon
- detergent-soluble fraction
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LHCGR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- male gonad development
- uterus development
- regulation of steroid hormone biosynthetic process
- ovulation cycle process
- response to xenobiotic stimulus
- protein targeting to lysosome
- hormone-mediated signaling pathway
- positive regulation of calcium-mediated signaling
- cellular response to luteinizing hormone stimulus
- cellular response to gonadotropin stimulus
- cognition
- seminiferous tubule development
- activation of adenylate cyclase activity
- positive regulation of inositol trisphosphate biosynthetic process
- G-protein coupled receptor signaling pathway
- G-protein coupled receptor signaling pathway, coupled to cyclic nucleotide second messenger
- spermatogenesis
- positive regulation of hormone biosynthetic process
- development of secondary male sexual characteristics
- positive regulation of release of sequestered calcium ion into cytosol
- phospholipase C-activating G-protein coupled receptor signaling pathway
- adenylate cyclase-activating G-protein coupled receptor signaling pathway
- luteinizing hormone signaling pathway
- ovarian follicle development
- arachidonic acid secretion
- male genitalia development
- positive regulation of calcium ion transport into cytosol
Cellular Component
Where in the cell the gene product is active
- extracellular space
- endosome
- centriolar satellite
- receptor complex
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- luteinizing hormone receptor activity
- identical protein binding
- G-protein coupled peptide receptor activity
- choriogonadotropin hormone receptor activity
- peptide hormone binding
- choriogonadotropin hormone binding
- ATPase binding