ANXA3 Gene Summary [Human]
This gene encodes a member of the annexin family. Members of this calcium-dependent phospholipid-binding protein family play a role in the regulation of cellular growth and in signal transduction pathways. This protein functions in the inhibition of phopholipase A2 and cleavage of inositol 1,2-cyclic phosphate to form inositol 1-phosphate. This protein may also play a role in anti-coagulation. [provided by RefSeq, Jul 2008]
Details
| Type | Protein Coding |
| Official Symbol | ANXA3 |
| Official Name | annexin A3 [Source:HGNC Symbol;Acc:HGNC:541] |
| Ensembl ID | ENSG00000138772 |
| Bio databases IDs | |
| Aliases | annexin A3 |
| Synonyms | annexin A3, ANX3, LC3, LIPOCORTIN III, LRRGT00047 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human ANXA3 often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- glycerophosphoinositol inositolphosphodiesterase
- calcium-dependent protein binding
- calcium-dependent phospholipid binding
- Annexin
- enzyme
- phospholipase A2 inhibitor
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- osteoarthritis
- epithelial neoplasia
- epithelial cancer
- cancer
- sepsis
- psoriasis
- colorectal adenoma
- colorectal adenoma formation
- systemic autoimmune syndrome
- androgenic alopecia
regulates
- transcription factor
role in cell
- migration
- phagocytosis by
- degranulation
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cellular membrane
- Nucleus
- Plasma Membrane
- Golgi Apparatus
- cytosol
- neurites
- specific granules
- perikaryon
- axons
- dendrites
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human ANXA3 gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- response to growth factor stimulus
- response to glucocorticoid stimulus
- positive regulation of DNA metabolic process
- phagocytosis
- hippocampus development
- neutrophil degranulation
- organ regeneration
- positive regulation of sequence-specific DNA binding transcription factor activity
- positive regulation of endothelial cell migration
- defense response to bacterium
- positive regulation of angiogenesis
Cellular Component
Where in the cell the gene product is active
- dendrite
- nucleus
- extracellular vesicular exosome
- cytoplasm
- specific granule
- vesicle membrane
- membrane
- phagocytic vesicle membrane
- neuronal cell body
- axon
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- phosphatidylserine binding
- calcium ion binding
- calcium-dependent protein binding
- phospholipase A2 inhibitor activity
- calcium-dependent phospholipid binding