VPS37B Gene Summary [Human]
Enables calcium-dependent protein binding activity. Involved in positive regulation of viral budding via host ESCRT complex. Located in endosome membrane; midbody; and plasma membrane. Part of ESCRT I complex. [provided by Alliance of Genome Resources, Apr 2022]
Details
| Type | Protein Coding |
| Official Symbol | VPS37B |
| Official Name | VPS37B subunit of ESCRT-I [Source:HGNC Symbol;Acc:HGNC:25754] |
| Ensembl ID | ENSG00000139722 |
| Bio databases IDs | |
| Aliases | VPS37B subunit of ESCRT-I |
| Synonyms | 2300007F24Rik, FLJ12750, image:4163734, RGD1304576, vacuolar protein sorting 37B, VPS37B subunit of ESCRT-I |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human VPS37B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calcium-dependent protein binding
- Modifier of rudimentary (Mod(r)) protein
- protein binding
Pathways
Biological processes and signaling networks where the VPS37B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- Plasma Membrane
- endosomes
- midbody
- endosomal membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human VPS37B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- protein targeting to vacuole involved in ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- membrane fission
- release of virus from host
- ubiquitin-dependent protein catabolic process via the multivesicular body sorting pathway
- protein targeting to vacuole
- protein targeting to membrane
- macroautophagy
Cellular Component
Where in the cell the gene product is active
- late endosome membrane
- endosome
- extracellular vesicular exosome
- cytoplasm
- ESCRT I complex
- endosome membrane
- midbody
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- protein binding
- calcium-dependent protein binding