MTBP Gene Summary [Human]
This gene encodes a protein that interacts with the oncoprotein mouse double minute 2. The encoded protein regulates progression through the cell cycle and may be involved in tumor formation. [provided by RefSeq, Aug 2012]
Details
| Type | Retained Intron |
| Official Symbol | MTBP |
| Official Name | MDM2 binding protein [Source:HGNC Symbol;Acc:HGNC:7417] |
| Ensembl ID | ENSG00000172167 |
| Bio databases IDs | |
| Aliases | MDM2 binding protein |
| Synonyms | LOC102552118, MDM2 binding protein, MDM2BP, Mdm2, transformed 3T3 cell double minute p53 binding protein, RGD1565672 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MTBP often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- protein binding
- MDM2-binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- neoplasia
- metastasis
- lymphomagenesis
- lung adenocarcinoma
- lung adenocarcinoma formation
- gastritis
- hepatitis A
- neoplastic cell transformation
role in cell
- formation
- proliferation
- cell death
- migration
- survival
- colony formation
- migratory capacity
- transformation
- S phase
- binding
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Nucleus
- kinetochores
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MTBP gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of mitosis
- negative regulation of cell proliferation
- protein localization to kinetochore
- traversing start control point of mitotic cell cycle
- regulation of protein ubiquitination
Cellular Component
Where in the cell the gene product is active
- kinetochore
- chromatin