MYO18A Gene Summary [Human]
The protein encoded by this gene can bind GOLPH3, linking the Golgi to the cytoskeleton and influencing Golgi membrane trafficking. The encoded protein is also part of a complex that assembles lamellar actomyosin bundles and may be required for cell migration. [provided by RefSeq, Oct 2016]
Details
| Type | Protein Coding |
| Official Symbol | MYO18A |
| Official Name | myosin XVIIIA [Source:HGNC Symbol;Acc:HGNC:31104] |
| Ensembl ID | ENSG00000196535 |
| Bio databases IDs | |
| Aliases | myosin XVIIIA |
| Synonyms | LOC103693393, LOC360570, MAJN, MyoPDZ, myosin XVIIIA, MYSPDZ, SP-R210, TIAF1 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MYO18A often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Nuf2, DHR10-like domain
- Tail length tape measure protein
- helix-rich Mycoplasma protein
- TATA element modulatory factor 1 TATA binding
- motor domain
- Putative golgin subfamily A member 2-like protein 5
- Tropomyosin
- Calmodulin-binding motif
- Family with sequence similarity 184, A and B
- Domain of unknown function (DUF4455)
- Coiled-coil domain-containing protein 154
- Mitotic checkpoint protein
- SPEC
- Crescentin protein
- Domain present in PSD-95, Dlg, and ZO-1/2
- Rabaptin-like protein
- chromosome segregation protein SMC, primarily archaeal type
- exonuclease SbcC
- Weak chloroplast movement under blue light
- PspA/IM30 family
- Myosin and Kinesin motor domain
- Myosin tail
- SWI5-dependent HO expression protein 3
- protein binding
- Myosin head (motor domain)
- glutamic acid-lysine rich domain
- Mechanosensitive ion channel porin domain
- RIM-binding protein of the cytomatrix active zone
- Trichohyalin-plectin-homology domain
- Coiled-coil domain-containing protein 158
- Intermediate filament protein
- Septation ring formation regulator, EzrA
- Myosin
- Uncharacterized conserved protein H4 (DUF2046)
- ADP binding
- Synaptonemal complex protein 1 (SCP-1)
- Autophagy protein ATG17-like domain
- ATP binding
- Golgin subfamily A member 5
- chromosome segregation protein SMC, common bacterial type
- Prefoldin subunit
- Leucine-rich repeats of kinetochore protein Cenp-F/LEK1
- HOOK protein coiled-coil region
- Tropomyosin like
- Ezrin/radixin/moesin, alpha-helical domain
- Hyaluronan mediated motility receptor N-terminal
- ALIX V-shaped domain binding to HIV
- Domain of unknown function (DUF4795)
- Uso1 / p115 like vesicle tethering protein, C terminal region
- canonical PDZ domain
- Rabaptin
- Calcium binding and coiled-coil domain (CALCOCO1) like
- PDZ domain
- actin filament binding
- RecF/RecN/SMC N terminal domain
- Domain of unknown function (DUF4686)
- SynN
- prefoldin
- Growth-arrest specific micro-tubule binding
- Domain of unknown function (DUF4200)
Pathways
Biological processes and signaling networks where the MYO18A gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- major depression
- colorectal cancer
regulates
- adenosine triphosphate
- Vsvg
- PAK2
role in cell
- apoptosis
- formation
- migration
- survival
- morphology
- activation
- number
- organization
- response by
- accumulation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- cytoskeleton
- actin cytoskeleton
- Nucleus
- Golgi Apparatus
- Endoplasmic Reticulum
- membrane ruffles
- trans Golgi network
- brush border
- phagosomes
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MYO18A gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- actomyosin structure organization
- Golgi organization
- asymmetric Golgi ribbon formation
- DNA metabolic process
- I-kappaB kinase/NF-kappaB cascade
- Golgi ribbon formation
- regulation of macrophage activation
- negative regulation of apoptotic process
- apoptotic process
- positive regulation of protein secretion
- Golgi vesicle budding
- cell migration
Cellular Component
Where in the cell the gene product is active
- nucleus
- trans-Golgi network
- microtubule organizing center
- cytoplasm
- membrane
- myosin II complex
- myosin filament
- Golgi membrane
- actomyosin
- endoplasmic reticulum-Golgi intermediate compartment
- cell surface
Molecular Function
What the gene product does at the molecular level
- actin filament binding
- ATPase activity
- ATP binding
- DNA binding
- DNA-dependent ATPase activity
- RNA binding
- protein binding
- ADP binding