MEP1B Gene Summary [Human]
Meprins are multidomain zinc metalloproteases that are highly expressed in mammalian kidney and intestinal brush border membranes, and in leukocytes and certain cancer cells. They are involved in the hydrolysis of a variety of peptide and protein substrates, and have been implicated in cancer and intestinal inflammation. Mature meprins are oligomers of evolutionarily related, but separately encoded alpha and/or beta subunits. Homooligomers of alpha subunit are secreted, whereas, oligomers containing the beta subunit are plasma membrane-bound. This gene encodes the beta subunit. Targeted disruption of this gene in mice affects embryonic viability, renal gene expression profiles, and distribution of the membrane-associated alpha subunit in kidney and intestine. [provided by RefSeq, Oct 2011]
Details
| Type | Processed Transcript |
| Official Symbol | MEP1B |
| Official Name | meprin A subunit beta [Source:HGNC Symbol;Acc:HGNC:7020] |
| Ensembl ID | ENSG00000141434 |
| Bio databases IDs | |
| Aliases | meprin A subunit beta |
| Synonyms | Endopeptidase-2, LOC100911405, LOC102554362, meprin 1 beta, meprin 1 β, Meprin a subunit beta, Meprin a subunit β, Meprin Beta, Meprin β |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human MEP1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- MATH
- ectodomain
- peptidase
- Astacin (Peptidase family M12A)
- Human growth factor-like EGF
- protein domain specific binding
- Zinc-dependent metalloprotease
- protein binding
- identical protein binding
- EGF_CA
- ZnMc
- Domain in meprin, A5, receptor protein tyrosine phosphatase mu (and others)
- intracellular domain
- MAM domain, meprin/A5/mu
- metalloendopeptidase
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- reperfusion injury
- diabetes mellitus
- nonalcoholic steatohepatitis
- chronic allograft nephropathy
- nonalcoholic fatty liver disease
- weight gain
role in cell
- migration
- generation in
- loss
- processing in
- molecular cleavage in
- phagocytic capacity
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Plasma Membrane
- cellular membrane
- apical membrane
- brush border
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human MEP1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- inflammatory response
- proteolysis
Cellular Component
Where in the cell the gene product is active
- extracellular region
- plasma membrane
- meprin A complex
Molecular Function
What the gene product does at the molecular level
- zinc ion binding
- identical protein binding
- protein binding
- metalloendopeptidase activity