SELENOK Gene Summary [Human]
The protein encoded by this gene belongs to the selenoprotein K family. It is a transmembrane protein that is localized in the endoplasmic reticulum (ER), and is involved in ER-associated degradation (ERAD) of misfolded, glycosylated proteins. It also has a role in the protection of cells from ER stress-induced apoptosis. Knockout studies in mice show the importance of this gene in promoting Ca(2+) flux in immune cells and mounting effective immune response. This protein is a selenoprotein, containing the rare amino acid selenocysteine (Sec). Sec is encoded by the UGA codon, which normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, designated the Sec insertion sequence (SECIS) element, that is necessary for the recognition of UGA as a Sec codon, rather than as a stop signal. Pseudogenes of this locus have been identified on chromosomes 6 and 19.[provided by RefSeq, Aug 2017]
Details
| Type | Protein Coding |
| Official Symbol | SELENOK |
| Official Name | selenoprotein K [Source:HGNC Symbol;Acc:HGNC:30394] |
| Ensembl ID | ENSG00000113811 |
| Bio databases IDs | |
| Aliases | selenoprotein K |
| Synonyms | 1110001C03Rik, Hsp30, HSPC030, HSPC297, selenoprotein K, SELK |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human SELENOK often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- calpain cleavage site
- protein binding
- Selenoprotein SelK_SelG
- identical protein binding
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- atopic dermatitis
- infection by Flaviviridae
role in cell
- expression in
- phosphorylation in
- proliferation
- replication in
- chemotaxis
- function
- differentiation
- migration by
- cellular infiltration by
- oligomerization in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Cytoplasm
- Endoplasmic Reticulum
- endoplasmic reticulum membrane
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human SELENOK gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- respiratory burst after phagocytosis
- positive regulation of monocyte chemotactic protein-1 production
- positive regulation of defense response to virus by host
- positive regulation of T cell proliferation
- positive regulation of T cell migration
- response to oxidative stress
- regulation of protein transport
- calcium ion transport
- T cell proliferation
- T cell migration
- macrophage derived foam cell differentiation
- regulation of calcium-mediated signaling
- protein palmitoylation
- positive regulation of tumor necrosis factor production
- intrinsic apoptotic signaling pathway in response to endoplasmic reticulum stress
- establishment of localization in cell
- endoplasmic reticulum calcium ion homeostasis
- positive regulation of interleukin-6 production
Cellular Component
Where in the cell the gene product is active
- endoplasmic reticulum membrane
- endoplasmic reticulum
- Golgi apparatus
- plasma membrane
Molecular Function
What the gene product does at the molecular level
- identical protein binding
- protein binding