LCOR Gene Summary [Human]
LCOR is a transcriptional corepressor widely expressed in fetal and adult tissues that is recruited to agonist-bound nuclear receptors through a single LxxLL motif, also referred to as a nuclear receptor (NR) box (Fernandes et al., 2003 [PubMed 12535528]).[supplied by OMIM, Mar 2008]
Details
| Type | Nonsense Mediated Decay |
| Official Symbol | LCOR |
| Official Name | ligand dependent nuclear receptor corepressor [Source:HGNC Symbol;Acc:HGNC:29503] |
| Ensembl ID | ENSG00000196233 |
| Bio databases IDs | |
| Aliases | ligand dependent nuclear receptor corepressor |
| Synonyms | 3110023F06Rik, A630025C20Rik, C10orf12, FLJ13022, Gm340, KIAA1795, ligand dependent nuclear receptor corepressor, LOC100911430, LOC679031, mKIAA1795, MLR2, NEWGENE 1311704, RGD1311704 |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human LCOR often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- Domain of unknown function (DUF4553)
- transcription regulator
- LXXLL motif
- protease binding
- transcription co-repressor
- enzyme binding
- transcription factor binding
- histone deacetylase binding
- chromatin binding
- protein binding
- helix-turn-helix domain
- estrogen receptor binding
- helix-turn-helix, Psq domain
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- ulcerative colitis
- plasma cell myeloma
- prostate cancer
- myopathy
role in cell
- proliferation
- expression in
- inhibition in
- transcription in
- repression in
- transactivation in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nucleoplasm
- nuclear bodies
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human LCOR gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- negative regulation of transcription from RNA polymerase II promoter
- cellular response to estradiol stimulus
- regulation of transcription from RNA polymerase II promoter
Cellular Component
Where in the cell the gene product is active
- nucleus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- transcription corepressor binding
- DNA binding
- protein binding
- histone deacetylase binding
- transcription corepressor activity
- estrogen receptor binding