TAF1B Gene Summary [Human]
Initiation of transcription by RNA polymerase I requires the formation of a complex composed of the TATA-binding protein (TBP) and three TBP-associated factors (TAFs) specific for RNA polymerase I. This complex, known as SL1, binds to the core promoter of ribosomal RNA genes to position the polymerase properly and acts as a channel for regulatory signals. This gene encodes one of the SL1-specific TAFs. Multiple transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jan 2016]
Details
| Type | Protein Coding |
| Official Symbol | TAF1B |
| Official Name | TATA-box binding protein associated factor, RNA polymerase I subunit B [Source:HGNC Symbol;Acc:HGNC:11533] |
| Ensembl ID | ENSG00000115750 |
| Bio databases IDs | |
| Aliases | TATA-box binding protein associated factor, RNA polymerase I subunit B |
| Synonyms | 4930408G01Rik, A230108M10RIK, LOC686562, MGC:9349, p63, RAF1B, RAFI63, SL1, TAFI63, TAFI68, Tafi86, TATA-box binding protein associated factor, RNA polymerase I, B, TATA-box binding protein associated factor, RNA polymerase I subunit B, TIF1B |
| Species | Human, Homo sapiens |
| Orthologies |
Protein Domains
A protein domain is a distinct structural or functional region within a protein that can evolve, function, and exist independently of the rest of the protein chain. These domains in human TAF1B often fold into stable, three-dimensional structures and are associated with specific biological functions, such as binding to DNA, other proteins, or small molecules.
- transcription regulator
- double-stranded DNA binding
- nucleic acid binding
- Zinc-finger of RNA-polymerase I-specific TFIIB, Rrn7
- protein binding
- sequence-specific DNA binding
- acidic domain
- TATA-binding protein binding
Pathways
Biological processes and signaling networks where the TAF1B gene in human plays a role, providing insight into its function and relevance in health or disease.
Top Findings
The most significant associations for this gene, including commonly observed domains, pathway involvement, and functional highlights based on current data.
disease
- hepatocellular carcinoma
- organismal death
- liver cancer
- epithelial cancer
role in cell
- expression in
- apoptosis
- proliferation
- cell viability
- molecular cleavage in
- transcription in
Subcellular Expression
Locations within the cell where the protein is known or predicted to be active, providing insight into its function and cellular context.
- Nucleus
- nuclear fraction
- nucleoplasm
- nucleoli
- chromatin
Gene Ontology Annotations
Describes the biological processes, cellular components, and molecular functions associated with the human TAF1B gene, providing context for its role in the cell.
Biological Process
Functions and activities the gene product is involved in
- RNA polymerase I transcriptional preinitiation complex assembly
- transcription, DNA-dependent
- transcription of nuclear large rRNA transcript from RNA polymerase I promoter
Cellular Component
Where in the cell the gene product is active
- RNA polymerase transcription factor SL1 complex
- nucleus
- RNA polymerase I core factor complex
- nucleolus
- nucleoplasm
Molecular Function
What the gene product does at the molecular level
- protein binding
- RNA polymerase I CORE element sequence-specific DNA binding
- metal ion binding
- TBP-class protein binding